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IGF-1R protein expression is negatively correlated with let-7c expression We utilized the miRDB database bioinformational analysis and found that IGF-1R was one member of the target genes of hsa-let-7c with a target score up to 91 points

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A well-structured protocol for a 65-year-old with suboptimal IGF-1, sarcopenia, and visceral adiposity might look like this: Baseline labs IGF-1, GH stimulation assessment, HbA1c, fasting insulin, CMP, CBC, lipid panel, PSA (men), thyroid panel, DEXA scan for bone density Peptide selection typically sermorelin or low-dose CJC-1295/ipamorelin for GH axis support